Transferable quinolone resistance in Vibrio cholerae.

  title={Transferable quinolone resistance in Vibrio cholerae.},
  author={Hong Bin Kim and Minghua Wang and Sabeena Ahmed and Chi Hye Park and Regina C. Larocque and Abu S. G. Faruque and Mohammed Abdus Salam and Wasif Ali Zafarali Khan and Firdausi Qadri and Stephen B. Calderwood and George A. Jacoby and David C. Hooper},
  journal={Antimicrobial agents and chemotherapy},
  volume={54 2},
Ciprofloxacin was introduced for treatment of patients with cholera in Bangladesh because of resistance to other agents, but its utility has been compromised by the decreasing ciprofloxacin susceptibility of Vibrio cholerae over time. We correlated levels of susceptibility and temporal patterns with the occurrence of mutation in gyrA, which encodes a subunit of DNA gyrase, followed by mutation in parC, which encodes a subunit of DNA topoisomerase IV. We found that ciprofloxacin activity was… CONTINUE READING
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