Transferable mechanisms of quinolone resistance.

  title={Transferable mechanisms of quinolone resistance.},
  author={Joaquim Ruiz and Mar{\'i}a Jos{\'e} Pons and Cl{\'a}udia Gomes},
  journal={International journal of antimicrobial agents},
  volume={40 3},
Quinolones were introduced into clinical practice in the late 1960s. Although quinolone resistance was described early, no transferable mechanism of quinolone resistance (TMQR) was confirmed until 1998. To date, five different TMQRs have been described in the literature, including target protection (Qnr), quinolone modification (AAC(6')-Ib-cr), plasmid-encoded efflux systems (e.g. QepA or OqxAB, amongst others), effect on bacterial growth rates and natural transformation. Although TMQRs usually… CONTINUE READING
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