Transferable antibiotic resistance elements in Haemophilus influenzae share a common evolutionary origin with a diverse family of syntenic genomic islands.

@article{MohdZain2004TransferableAR,
  title={Transferable antibiotic resistance elements in Haemophilus influenzae share a common evolutionary origin with a diverse family of syntenic genomic islands.},
  author={Zaini Mohd-Zain and Sarah Lea Turner and Ana Cerde{\~n}o-T{\'a}rraga and Andrew K. Lilley and Thomas J. Inzana and Alison J. Duncan and Rosalind M. Harding and Derek W Hood and Timothy E. A. Peto and Derrick W. Crook},
  journal={Journal of bacteriology},
  year={2004},
  volume={186 23},
  pages={
          8114-22
        }
}
Transferable antibiotic resistance in Haemophilus influenzae was first detected in the early 1970s. After this, resistance spread rapidly worldwide and was shown to be transferred by a large 40- to 60-kb conjugative element. Bioinformatics analysis of the complete sequence of a typical H. influenzae conjugative resistance element, ICEHin1056, revealed the shared evolutionary origin of this element. ICEHin1056 has homology to 20 contiguous sequences in the National Center for Biotechnology… CONTINUE READING
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