Transferability of a modified embryonic stem cell test using a new endpoint for developmental neurotoxicity.

@article{Baek2012TransferabilityOA,
  title={Transferability of a modified embryonic stem cell test using a new endpoint for developmental neurotoxicity.},
  author={Dae Hyun Baek and Su-Yeon An and Jae Hyun Park and Youngju Choi and Ki Dae Park and Jin Wook Kang and Kyoung Suk Choi and Sung Hee Park and Min Young Whang and Jiyou Han and Jong-Hoon Kim and Hyung Soo Kim and Dongho Geum and Tae Moo Yoo},
  journal={Toxicology mechanisms and methods},
  year={2012},
  volume={22 2},
  pages={
          118-30
        }
}
We developed and analyzed a new surrogate endpoint of the mouse embryonic stem cell test (EST) for developmental neurotoxicity. To determine the sensitivity, specificity, and transferability of the new endpoint, a pre-validation team from three independent laboratories optimized and standardized the protocol for neuronal differentiation of mouse embryonic stem cells (mESCs) by measuring the neuronal differentiation rates of mESCs under different culture conditions, such as the presence or… CONTINUE READING
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