Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus.

@article{Munyon1971TransferOT,
  title={Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus.},
  author={W H Munyon and Edmundo Kraiselburd and Duane Davis and Jelena Mann},
  journal={Journal of virology},
  year={1971},
  volume={7 6},
  pages={813-20}
}
L cells lacking thymidine kinase (TK) activity (Ltk(-) cells) have been stably transformed to a TK-positive phenotype by infection with ultraviolet-irradiated herpes simplex virus (HSV-UV). The highest frequency of the Ltk(-) to Ltk(+) transformation observed in these experiments was approximately 10(-3), whereas no measurable transformation was observed (less than 10(-8)) in the absence of HSV-UV infection. Cell lines of HSV-transformed Ltk(+) cell lines contain 7 to 24 times as much TK… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Herpesvirus DNA

  • Developments in Molecular Virology
  • 1981
Highly Influenced
10 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Enhance - ment of viral transformation by ultra - violet light

  • B. McAuslan
  • Int . J . Radiat . Biol .
  • 1970

Incidence of EB virus - containing cells in primat - y and seconadry clones of several Burkitt lymphomiia cell lines

  • R. Kahn
  • Cancer Res .
  • 1970

Transformiia - tion of foetal human leukocytes in vitro by filtrates of al human leukemic cell line containing herpes - like virus

  • B. Roizman, D. Roane
  • 1968

Studies on tliymidine kinase in cultured mouse fibroblasts

  • N. J. Rosebrough, A. L. Farr, R. J. Randall
  • Biochim . Biophys . Acta
  • 1965

Effects of 5 - fluorouracil , actinomycin D and mitomycin C on the induction of thymidine kinase by vaccinia infected L - cells

  • H. Klemperer, G. Haynes, W. Shedden
  • J . Mol . Biol .
  • 1963

Similar Papers

Loading similar papers…