Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's disease.

@article{Yamada2003TransferOT,
  title={Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's disease.},
  author={Hidekazu Yamada and Mari Dezawa and Seiichiro Shimazu and Masaya Baba and Hajime Sawada and Yoshiyuki Kuroiwa and Isao Yamamoto and Hiroshi Kanno},
  journal={Annals of neurology},
  year={2003},
  volume={54 3},
  pages={352-9}
}
Neuronal progenitor cells (NPCs) may provide dopaminergic neurons for the treatment of Parkinson's disease (PD). However, transplantation of NPCs into the striatum by current methods has had limited success. It is possible to reverse the symptoms of PD in model rats but difficult to reverse them in humans because the number of dopaminergic neurons generated from NPCs is low. We transduced the von Hippel-Lindau (VHL) gene into NPCs isolated from embryonic rat brain. The NPCs with the transduced… CONTINUE READING