Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.

@article{Ierino1999TransferOS,
  title={Transfer of swine major histocompatibility complex class II genes into autologous bone marrow cells of baboons for the induction of tolerance across xenogeneic barriers.},
  author={Francesco Libero Ierino and Satoshi Gojo and Papia Banerjee and Maria Giovino and Yuanxin Xu and Julien Gere and Campbell Kaynor and Michel Awwad and R. M. Monroy and James L Rembert and Tevis Hatch and Anne Foley and Tomasz Kozlowski and Kazuhiko Yamada and Francisca A Neethling and Jay A Fishman and Michael T Bailin and Thomas R. Spitzer and David K C Cooper and A. Benedict Cosimi and Christian Leguern and David H Sachs},
  journal={Transplantation},
  year={1999},
  volume={67 8},
  pages={1119-28}
}
BACKGROUND The present study examined the potential role of gene therapy in the induction of tolerance to anti-porcine major histocompatibility complex (SLA) class II-mediated responses after porcine renal or skin xenografts. METHODS Baboons were treated with a non-myeloablative or a myeloablative preparative regimen before bone marrow transplantation with autologous bone marrow cells retrovirally transduced to express both SLA class II DR and neomycin phosphotransferase (NeoR) genes, or the… CONTINUE READING