Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development.

@article{Nishimura2003TransferON,
  title={Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development.},
  author={Yoshiaki Nishimura and Tatsuhiko Igarashi and Nancy L Haigwood and Reza Sadjadpour and Olivia K. Donau and Charles E. Buckler and Ron J Plishka and ALICIA J. BUCKLER-WHITE and Malcolm A Martin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 25},
  pages={15131-6}
}
Passive transfer of high-titered antiviral neutralizing IgG, known to confer sterilizing immunity in pig-tailed monkeys, has been used to determine how soon after virus exposure neutralizing antibodies (NAbs) must be present to block a simian immunodeficiency virus (SIV)/HIV chimeric virus infection. Sterilizing protection was achieved in three of four macaques receiving neutralizing IgG 6 h after intravenous SIV/HIV chimeric virus inoculation as monitored by PCR analyses of and attempted virus… CONTINUE READING