Transfer of immediate hypersensitivity and airway hyperresponsiveness by IgE-positive B cells.

@article{Lack1995TransferOI,
  title={Transfer of immediate hypersensitivity and airway hyperresponsiveness by IgE-positive B cells.},
  author={Gideon Lack and Akihiro Oshiba and Karen L Bradley and Joan E. Loader and D Amran and G L Drake Larsen and Erwin W. Gelfand},
  journal={American journal of respiratory and critical care medicine},
  year={1995},
  volume={152 6 Pt 1},
  pages={1765-73}
}
The role of allergen-specific sIgE+ B cells in the development of airway hyperresponsiveness to electrical field stimulation was examined in a murine model of allergic sensitization. Ovalbumin (OVA)-specific B cells (OVA+) were isolated from mice that were sensitized to aerosolized OVA. The OVA+ B cell population was shown to be distinct from the remaining, non-OVA-responsive B cells (OVA-). There was a high frequency of sIgE+ B cells and a low frequency of sIgG+ B cells in the OVA+ population… CONTINUE READING
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