Transfer of embryonic nuclei to fertilised mouse eggs and development of tetraploid blastocysts

@article{Modliski1978TransferOE,
  title={Transfer of embryonic nuclei to fertilised mouse eggs and development of tetraploid blastocysts},
  author={Jacek A. Modliński},
  journal={Nature},
  year={1978},
  volume={273},
  pages={466-467}
}
THE transfer of nuclei from embryonic or differentiated cells into eggs is the most sensitive method of testing whether those nuclei change irreversibly during development. However, among the metazoa its use has been restricted to amphibians and insects1,2 because of problems associated with the microsurgery of the very small and delicate mammalian egg. A few attempts have been made to introduce somatic nuclei into unfertilised mouse oocytes or blastomeres with the help of virus-mediated cell… CONTINUE READING