Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.

@article{Martnez2006TransferOD,
  title={Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens.},
  author={Mar{\'i}a del Carmen Mart{\'i}nez and Fr{\'e}d{\'e}ric Larbret and Fatiha Zobairi and Jos{\'e}e Coulombe and Najet Debili and William Vainchenker and Martial Ruat and J. -M. Freyssinet},
  journal={Blood},
  year={2006},
  volume={108 9},
  pages={3012-20}
}
Hedgehog (Hh) proteins are considered diffusible morphogens that can be membrane anchored, playing an essential role during development. Here we show that Hh morphogens are associated with microvesicles (MVs) shed from the plasma membrane of apoptotic/stimulated T cells. Hh+ MVs induced differentiation of human K562 pluripotent erythroleukemic cells toward megakaryocytic lineage, as testified to by the expression of alpha(IIb)beta3 integrin and CD42b and changes in the cell cycle. Blocking Hh… CONTINUE READING