Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of alpha1A.

@article{Dring1996TransferOL,
  title={Transfer of L-type calcium channel IVS6 segment increases phenylalkylamine sensitivity of alpha1A.},
  author={Frank D{\"o}ring and V E Degtiar and M. Grabner and J{\"o}rg Striessnig and Steffen Hering and Hartmut Glossman},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 20},
  pages={11745-9}
}
Conditioned ("use-dependent") inhibition by phenylalkylamines (PAAs) is a characteristic property of L- type calcium (Ca2+) channels. To determine the structural elements of the PAA binding domain we transferred sequence stretches of the pore-forming regions of repeat III and/or IV from the skeletal muscle alpha1 subunit (alpha1S) to the class A alpha1 subunit (alpha1A and expressed these chimeras together with beta1a and alpha2/delta subunits in Xenopus oocytes. The corresponding barium… CONTINUE READING