Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.

  title={Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.},
  author={Li-Rung Huang and Yvonne A G{\"a}bel and Stefanie Graf and Silke Arzberger and Christian Kurts and Mathias Heikenwalder and Percy A. Knolle and Ulrike Protzer},
  volume={142 7},
Studies of mechanisms responsible for the persistence of hepatitis B virus (HBV) infection have been hindered by a lack of appropriate animal models. HBV genomes can be delivered to livers of mice using hydrodynamic injection or high doses of an adenoviral vector; these lead to clearance of HBV. We found that infection of immunocompetent mice with low doses of an adenoviral vector resulted in persistent HBV infection; the mice neither underwent seroconversion to production of antibodies against… 

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