Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

@article{YlHerttuala1995TransferO1,
  title={Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.},
  author={Seppo Yl{\"a}-Herttuala and Jukka S. Luoma and Helena Viita and Timo P Hiltunen and Tero Sisto and Tapio Nikkari},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 6},
  pages={
          2692-8
        }
}
Oxidized low density lipoprotein (LDL) possesses several atherogenic properties. The mechanisms by which LDL becomes oxidized in vivo remain unknown, but previous studies have suggested that 15-lipoxygenase may be one of the factors involved in the initiation of LDL oxidation in the arterial wall. 3 wk after a retrovirus-mediated 15-lipoxygenase gene transfer into iliac arteries of normocholesterolemic rabbits there was a threefold increase in 15-lipoxygenase activity but no signs of LDL… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

15-Lipoxygenase inhibitors: a patent review.

  • Expert opinion on therapeutic patents
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
VIEW 2 EXCERPTS
CITES METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions

Y. Yoshida, T. Imanaka, T. Takano
  • J . Biol . Chem .
  • 1994