Transfer and Metabolism of Retinol by the Perfused Human Placenta

  title={Transfer and Metabolism of Retinol by the Perfused Human Placenta},
  author={Joseph Dancis and Mortimer Levitz and Joseph Katz and David Wilson and William S. Blaner and Roseann Piantedosi and Dewitt S. Goodman},
  journal={Pediatric Research},
ABSTRACT: The transfer and metabolism of retinol by human placenta was investigated using an in vitro perfusion system with independent maternal and fetal circulations. 3H-retinol bound to albumin added to the maternal perfusate was rapidly taken up and concentrated by the placenta to levels 16.5 ± 5.28 times the maternal perfusate. Approximately 8% of the retinol retained in the placenta was esterified. No metabolites were detected in the perfusates. Perfusion of placenta with retinol bound to… CONTINUE READING


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