Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis.

@article{Nomanbhoy1999TransferRT,
  title={Transfer RNA-dependent translocation of misactivated amino acids to prevent errors in protein synthesis.},
  author={Tyzoon K. Nomanbhoy and Tamara L. Hendrickson and Paul R. Schimmel},
  journal={Molecular cell},
  year={1999},
  volume={4 4},
  pages={519-28}
}
Misactivation of amino acids by aminoacyl-tRNA synthetases can lead to significant errors in protein synthesis that are prevented by editing reactions. As an example, discrete sites in isoleucyl-tRNA synthetase for amino acid activation and editing are about 25 A apart. The details of how misactivated valine is translocated from one site to the other are unknown. Here, we present a kinetic study in which a fluorescent probe is used to monitor translocation of misactivated valine from the active… CONTINUE READING

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