• Biology, Medicine
  • Published in
    Journal of molecular biology…
    2014

Transfer RNA as a source of small functional RNA.

@article{Shigematsu2014TransferRA,
  title={Transfer RNA as a source of small functional RNA.},
  author={Megumi Shigematsu and Shozo Honda and Yohei Kirino},
  journal={Journal of molecular biology and molecular imaging},
  year={2014},
  volume={1 2}
}
Since their discovery in the 1950s, transfer RNAs (tRNAs) have been best known as adapter molecules that play a central role in translating genetic information. However, recent biochemical and bioinformatic evidence has led to a previously unexpected conceptual consensus that tRNAs are not always end products; they further serve as a source of small functional RNAs. In many organisms, specific tRNA fragments are produced from mature tRNAs or their precursor transcripts not as random degradation… CONTINUE READING

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