Transfection to Manufacturing: Reducing Timelines for High Yielding GS-CHO Processes

@inproceedings{Rendall2005TransfectionTM,
  title={Transfection to Manufacturing: Reducing Timelines for High Yielding GS-CHO Processes},
  author={Meredith Rendall and Anthony Maxwell and Daniel John Tatham and Protiti Khan and Robert Kallmeier and J Wayte and Andrew J. Racher},
  year={2005}
}
Chinese hamster ovary (CHO) cell lines are widely used by the bio-pharmaceutical industry for therapeutic protein manufacture. The rapid construction of high yielding recombinant CHO cell lines are a key economic consideration. Gene amplification is widely used to create high yielding CHO cell lines; however this can substantially increase the length of a cell line development programme. As a further consideration, adaptation to single cell suspension culture and to protein-free (or chemically… CONTINUE READING