Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer.

@article{Wagner1998TransfectionOT,
  title={Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer.},
  author={Martin Otto Werner Wagner and Joerg Kleeff and Martha E. Lopez and I Bockman and J Massaqu{\'e} and Murray Korc},
  journal={International journal of cancer},
  year={1998},
  volume={78 2},
  pages={255-60}
}
Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-beta1 in T3M4 human pancreatic cancer cells, which express low levels of TbetaRI and high levels of TbetaRII. Cells were transiently transfected with p3TP-Lux, a TGF-beta-responsive luciferase… CONTINUE READING

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