Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation.

  title={Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation.},
  author={Alain A Proulx and Z. X. Lin and Christian C. Naus},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  volume={8 5},
Normal cell physiological processes rely heavily on cues from the extracellular environment to coordinate the proper functioning of cellular activities. The intercellular communication that takes place through gap junctions in neighboring cells has been implicated in growth control and embryonic differentiation. Indeed, many tumorigenic cells induced to overexpress gap junction proteins exhibit increased differentiation and decreased cell proliferation. Although absent in mature skeletal muscle… CONTINUE READING
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