Transfection of pancreatic islets using polyvalent DNA-functionalized gold nanoparticles.

Abstract

BACKGROUND Transplantation of pancreatic islets is an effective treatment for select patients with type 1 diabetes. Improved cellular therapy results may be realized by altering the gene expression profile of transplanted islets. Current viral and nonviral vectors used to introduce nucleic acids for gene regulation hold promise, but safety and efficacy… (More)
DOI: 10.1016/j.surg.2010.05.013

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