Transfection of p27(Kip1) threonine residue 187 mutant type gene, which is not influenced by ubiquitin-mediated degradation, induces cell cycle arrest in oral squamous cell carcinoma cells.

Abstract

OBJECTIVE It is well known that reduction of the cyclin-dependent kinase inhibitor p27(Kip1) protein correlates with the malignant behavior of various cancers including oral squamous cell carcinoma (OSCC). The loss of p27(Kip1) protein is suggested to be due to the enhancement of its posttranslational degradation. In the present study, to evaluate the… (More)

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