Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning

@article{Brightwell2008TransfectionOM,
  title={Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning},
  author={Jennifer J. Brightwell and Clayton A. Smith and Rachael Lee Neve and Paul J. Colombo},
  journal={Neurobiology of Learning and Memory},
  year={2008},
  volume={89},
  pages={27-35}
}
Extensive research has shown that the striatum is necessary for response learning. We reported previously that rats using a response strategy to solve a cross maze task showed sustained phosphorylation of striatal CREB [Colombo, P. J., Brightwell, J. J., & Countryman, R. A. (2003). Cognitive strategy-specific increases in phosphorylated cAMP response element-binding protein and c-Fos in the hippocampus and dorsal striatum. Journal of Neuroscience, 23(8), 3547-3554], a transcription factor… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…