Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2.

  title={Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2.},
  author={Masato Shimizu and M Tsunogai and Shigeru Arai},
  volume={18 5},
The transepithelial transport of oligopeptides (of more than 4 residues) was studied by using human intestinal Caco-2 cell monolyers. The susceptibility to the brush-border peptidases was observed to be one of the primary factors which decide the transport rate. The apical-to-basolateral transport mechanism was investigated by using bradykinin and GGYR which were resistant to cellular peptidases. The intracellular pathway, probably the adsorptive transcytosis, was suggested to be involved in… CONTINUE READING
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