Transepidermal water loss: the signal for recovery of barrier structure and function.

  title={Transepidermal water loss: the signal for recovery of barrier structure and function.},
  author={G Grubauer and Peter M Elias and Kenneth R. Feingold},
  journal={Journal of lipid research},
  volume={30 3},
Previous studies have demonstrated that perturbations in barrier function stimulate epidermal lipid synthesis and that this increase can be prevented by occlusive membranes. These observations suggest that epidermal lipid synthesis might be related to barrier function and raised the question whether transcutaneous water flux might regulate epidermal lipogenesis. In the present study we first abrogated the barrier with acetone, and then compared the rate of repletion of stainable lipids, barrier… CONTINUE READING

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Lipids and the epidermal permeability barrier

Archives of Dermatological Research • 1981

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