Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots

@article{Shulman2011TransendothelialMO,
  title={Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots},
  author={Ziv Shulman and Shmuel Jaffe Cohen and Ben Roediger and Vyacheslav Kalchenko and Rohit Jain and Valentin Grabovsky and C. G. A. Harrison and Vera Shinder and Liat Stoler-Barak and Sara W. Feigelson and Tsipi Meshel and Susanna M. Nurmi and Itamar Goldstein and Olivier Hartley and Carl G Gahmberg and Amos Etzioni and Wolfgang Josef Weninger and Adit Ben-Baruch and Ronen Alon},
  journal={Nature Immunology},
  year={2011},
  volume={13},
  pages={67-76}
}
Chemokines presented by the endothelium are critical for integrin-dependent adhesion and transendothelial migration of naive and memory lymphocytes. Here we found that effector lymphocytes of the type 1 helper T cell (TH1 cell) and type 1 cytotoxic T cell (TC1 cell) subtypes expressed adhesive integrins that bypassed chemokine signals and established firm arrests on variably inflamed endothelial barriers. Nevertheless, the transendothelial migration of these lymphocytes strictly depended on… CONTINUE READING
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