Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis.

  title={Transendothelial migration enhances integrin-dependent human neutrophil chemokinesis.},
  author={Anjelica L Gonzalez and Wafa El-Bjeirami and Jennifer L West and L. V. Mcintire and Clifton Smith},
  journal={Journal of leukocyte biology},
  volume={81 3},
Transendothelial migration of neutrophils induces phenotypic changes that influence the interactions of neutrophils with extravascular tissue components. To assess the influence of transmigration on neutrophil chemokinetic motility, we used polyethylene glycol hydrogels covalently modified with specific peptide sequences relevant to extracellular matrix proteins. We evaluated fMLP-stimulated human neutrophil motility on peptides Arg-Gly-Asp-Ser (RGDS) and TMKIIPFNRTLIGG (P2), alone and in… CONTINUE READING

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