Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes.

@article{Medana2001TransectionOM,
  title={Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes.},
  author={Isabelle M. Medana and Marianne M Martinic and Hartmut Wekerle and Harald Neumann},
  journal={The American journal of pathology},
  year={2001},
  volume={159 3},
  pages={809-15}
}
Damage to neurites with transection of axons and spheroid formation is commonly noted in the central nervous system during viral and autoimmune diseases such as multiple sclerosis, but it remains open whether such changes are caused primarily by immune mechanisms or whether they are secondary to inflammation. The present experiments explored whether neurites can be directly attacked by cytotoxic T lymphocytes (CTLs). Cultured murine neurons induced by interferon-gamma and tetrodotoxin to… CONTINUE READING
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