Transduction of the inner mouse retina using AAVrh8 and AAVrh10 via intravitreal injection.

@article{Giove2010TransductionOT,
  title={Transduction of the inner mouse retina using AAVrh8 and AAVrh10 via intravitreal injection.},
  author={Thomas J. Giove and Miguel Sena-Esteves and William D. Eldred},
  journal={Experimental eye research},
  year={2010},
  volume={91 5},
  pages={652-9}
}
Adeno-associated virus (AAV) is a proven, safe and effective vector for gene delivery in the retina. There are over 100 serotypes of AAV, and AAV2 through AAV9 have been evaluated in the retina. Each AAV serotype has different cell tropism and transduction efficiency. Intravitreal injections of AAV into the eye tend to transduce cells in the ganglion cell layer (GCL), while subretinal injections tend to transduce retinal pigment epithelium and photoreceptors. Efficient transduction of the inner… CONTINUE READING

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