Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation.

@article{Cazac2003TransductionOL,
  title={Transduction of leptin growth signals in placental cells is independent of JAK-STAT activation.},
  author={Mich{\`e}le Ca{\"u}zac and D Czuba and Jean Girard and Sylvie Hauguel-de Mouzon},
  journal={Placenta},
  year={2003},
  volume={24 4},
  pages={
          378-84
        }
}
We have characterized the transduction pathways induced by leptin in the placenta, using human BeWo cells that express endogenous leptin receptors and synthesize leptin in a regulated manner. We first examined if the JAK-STAT phosphorylation cascade was functional in these cells. Phosphorylated JAK2 was primarily bound to a short 106kDa leptin receptor isoform and to a lesser extent to a 210kDa molecule. Leptin neither enhanced JAK2 phosphorylation nor activated STAT3 and STAT1 proteins… CONTINUE READING
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