Transduction of human melanoma cells with interleukin-2 gene reduces tumorigenicity and enhances host antitumor immunity: a nude mouse model.

@article{Abdelwahab1994TransductionOH,
  title={Transduction of human melanoma cells with interleukin-2 gene reduces tumorigenicity and enhances host antitumor immunity: a nude mouse model.},
  author={Z A Abdel-wahab and Wai Ping Li and Susanne Osanto and Timothy L. Darrow and J{\"o}rg Hessling and Carol E. Vervaert and M Burrascano and Jack R. Barber and Hillard F. Seigler},
  journal={Cellular immunology},
  year={1994},
  volume={159 1},
  pages={26-39}
}
Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mice. The gene-modified melanoma cells expressed the IL-2 cytokine gene and secreted biologically active IL-2. Transduction of melanoma cells with the IL-2 gene did not affect the… CONTINUE READING