Transduction of glycan-lectin binding using near-infrared fluorescent single-walled carbon nanotubes for glycan profiling.

@article{Reuel2011TransductionOG,
  title={Transduction of glycan-lectin binding using near-infrared fluorescent single-walled carbon nanotubes for glycan profiling.},
  author={Nigel F. Reuel and Jin-Ho Ahn and Jong-Ho Kim and Jingqing Zhang and Ardemis A. Boghossian and Lara K Mahal and Michael S. Strano},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 44},
  pages={17923-33}
}
There is significant interest in developing new detection platforms for characterizing glycosylated proteins, despite the lack of easily synthesized model glycans or high affinity receptors for this analytical problem. In this work, we demonstrate a sensor array employing recombinant lectins as glycan recognition sites tethered via Histidine tags to Ni(2+) complexes that act as fluorescent quenchers for semiconducting single-walled carbon nanotubes (SWNTs) embedded in a chitosan hydrogel spot… CONTINUE READING
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