Transduction of bitter and sweet taste by gustducin

@article{Wong1996TransductionOB,
  title={Transduction of bitter and sweet taste by gustducin},
  author={Gwendolyn T. Wong and Kimberley S. Gannon and Robert F Margolskee},
  journal={Nature},
  year={1996},
  volume={381},
  pages={796-800}
}
SEVERAL lines of evidence suggest that both sweet and bitter tastes are transduced via receptors coupled to heterotrimeric guanine-nucleotide-binding proteins (G proteins) (reviewed in refs 1, 2). Gustducin is a taste receptor cell (TRC)-specific G protein that is closely related to the transducins3. Gustducin and rod transducin, which is also expressed in TRCs (ref. 4), have been proposed to couple bitter-responsive receptors to TRC-specific phosphodiesterases to regulate intracellular cyclic… CONTINUE READING
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