Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration.

Abstract

OBJECTIVE To investigate cellular signaling mechanisms that influence chondrocyte production of inorganic pyrophosphate (PPi), which promotes calcium pyrophosphate dihydrate (CPPD) crystal deposition. METHODS Articular chondrocyte and cartilage cultures were stimulated with protein kinase C (PKC) activator and adenyl cyclase activator. Generation of… (More)

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