Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury

@article{Petrosyan2014TransductionEO,
  title={Transduction efficiency of neurons and glial cells by AAV-1, -5, -9, -rh10 and -hu11 serotypes in rat spinal cord following contusion injury},
  author={Hayk A. Petrosyan and Valentina Alessi and Vikrant Bhar Singh and Arsen S. Hunanyan and Joel M. Levine and Victor L. Arvanian},
  journal={Gene Therapy},
  year={2014},
  volume={21},
  pages={991-1000}
}
Adeno-associated viruses (AAVs) are a promising system for therapeutic gene delivery to neurons in a number of neurodegenerative conditions including spinal cord injuries (SCIs). Considering the role of macrophages and glia in the progression of ‘secondary damage’, we searched for the optimal vectors for gene transfer to both neurons and glia following contusion SCI in adult rats. Contusion models share many similarities to most human spinal cord traumas. Several AAV serotypes known for their… CONTINUE READING
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