Transducin β-like protein 1 recruits nuclear factor κB to the target gene promoter for transcriptional activation.

Nuclear factor κB (NF-κB) signaling controls a wide range of cellular functions such as tumor progression and invasion by inducing gene expression. Upon stimulation, NF-κB is translocated to the nucleus and binds to its target gene promoters to activate transcription by recruiting transcription coactivators. Although significant progress has been made in… CONTINUE READING