Transduced Schwann cells promote axon growth and myelination after spinal cord injury

@article{Golden2007TransducedSC,
  title={Transduced Schwann cells promote axon growth and myelination after spinal cord injury},
  author={Kevin Louis Golden and Damien D Pearse and Bas Blits and M. S. Garg and Mary Bartlett Bunge},
  journal={Experimental Neurology},
  year={2007},
  volume={207},
  pages={203-217}
}
We sought to directly compare growth and myelination of local and supraspinal axons by implanting into the injured spinal cord Schwann cells (SCs) transduced ex vivo with adenoviral (AdV) or lentiviral (LV) vectors encoding a bifunctional neurotrophin molecule (D15A). D15A mimics actions of both neurotrophin-3 and brain-derived neurotrophic factor. Transduced SCs were injected into the injury center 1 week after a moderate thoracic (T8) adult rat spinal cord contusion. D15A expression and… CONTINUE READING
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Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury.

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