Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice.

@article{Zhou2008TransducedPF,
  title={Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice.},
  author={Jian Zhou and Ze Feng and Ben Li Yuan and Shou Zhong Yu and Qian Li and Hen Yan Qu and Man Ji Sun},
  journal={Brain research},
  year={2008},
  volume={1191},
  pages={12-9}
}
Brain-derived neurotrophic factor (BDNF) promotes the survival and differentiation of hippocampal, cortical, and basal forebrain cholinergic neurons. However, the efficacy of BDNF via peripheral (i.v.) administration is limited by the lack of transport of the neurotrophin through the blood-brain barrier (BBB) in vivo. The present study describes that the i.v. administered recombinant human BDNF (rhBDNF) conjugated with a protein transduction domain (PTD ) is able to survive and promote the… CONTINUE READING

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