Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice.

  title={Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice.},
  author={So Young Kim and Eun Jeong Sohn and Dae Won Kim and Hoon Jae Jeong and Mi Jin Kim and Hye Won Kang and Min Jea Shin and Eun Hee Ahn and Soon Won Kwon and Young Nam Kim and Hyung Joo Kwon and Shyam Kishor Sah and Kil Soo Lee and Jae-Bong Park and Won Sik Eum and Soo Young Choi},
  journal={The Journal of investigative dermatology},
  volume={131 7},
Immunophilin, FK506-binding protein 12 (FK506BP), is a receptor protein for the immunosuppressive drug FK506 by the FK506BP/FK506 complex. However, the precise function of FK506BP in inflammatory diseases remains unclear. Therefore, we examined the protective effects of FK506BP on atopic dermatitis (AD) in tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ)-induced HaCaT cells and 2,4-dinitrofluorobenzene-induced AD-like dermatitis in Nishiki-nezumi Cinnamon/Nagoya (NC/Nga) mice using a cell… CONTINUE READING
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