Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis.

Abstract

RATIONALE Atherosclerosis is a widespread and devastating disease, but the origins of cells within atherosclerotic plaques are not well defined. OBJECTIVE To investigate the specific contribution of vascular smooth muscle cells (SMCs) to atherosclerotic plaque formation by genetic inducible fate mapping in mice. METHODS AND RESULTS Vascular SMCs were… (More)
DOI: 10.1161/CIRCRESAHA.115.304634

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