Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors.

Abstract

PURPOSE Liver transplantation is currently the only curative therapeutic option for end-stage liver cirrhosis. However, due to the limitations of donor liver availability and occasional rejection, it cannot always be successfully applied. In this study, we determined whether fibroblasts can be transdifferentiated into hepatocyte-like cells by transcription… (More)
DOI: 10.1007/s12072-013-9432-5

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