Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters

@article{Okura2009TransdifferentiationOH,
  title={Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters},
  author={Hanayuki Okura and Hiroshi Komoda and Yuichi Fumimoto and Chun-Man Lee and Toshirou Nishida and Yoshiki Sawa and Akifumi Matsuyama},
  journal={Journal of Artificial Organs},
  year={2009},
  volume={12},
  pages={123-130}
}
Type 1 diabetes mellitus is caused by autoimmune destruction of insulin-producing beta cells. The major obstacle to transplantation of insulin-producing cells to cure the disease is the limited source of these cells. To overcome this problem, we describe here a multistep protocol for generation of insulin-producing islet-like clusters from human adipose tissue-derived stromal cells (ADSCs). Analysis using reverse transcription polymerase chain reaction detected enhanced expression of various… CONTINUE READING
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