Transdifferentiation of brain-derived neurotrophic factor (BDNF)-secreting mesenchymal stem cells significantly enhance BDNF secretion and Schwann cell marker proteins.

Abstract

The use of genetically modified mesenchymal stem cells (MSCs) is a rapidly growing area of research targeting delivery of therapeutic factors for neuro-repair. Cells can be programmed to hypersecrete various growth/trophic factors such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor… (More)
DOI: 10.1016/j.jbiosc.2017.05.014

Topics

Cite this paper

@article{Rosa2017TransdifferentiationOB, title={Transdifferentiation of brain-derived neurotrophic factor (BDNF)-secreting mesenchymal stem cells significantly enhance BDNF secretion and Schwann cell marker proteins.}, author={Metzere Bierlein De la Rosa and Anup D. Sharma and S K Surya K Mallapragada and D S Donald S Sakaguchi}, journal={Journal of bioscience and bioengineering}, year={2017}, volume={124 5}, pages={572-582} }