Transdifferentiation-inducing HCCR-1 oncogene

  title={Transdifferentiation-inducing HCCR-1 oncogene},
  author={S W Ha and Hyun Kee Kim and Jinah Yoo and Sanghee Kim and Seung Min Shin and Youn Soo Lee and Soo Young Hur and Yong Wook Kim and Tae Eung Kim and Yeun Jun Chung and Shin Soo Jeun and Dong Whi Kim and Yong Gue Park and Jin Soo Kim and Soon Young Shin and Y Lee and Jin Woo Kim},
  booktitle={BMC Cell Biology},
Cell transdifferentiation is characterized by loss of some phenotypes along with acquisition of new phenotypes in differentiated cells. The differentiated state of a given cell is not irreversible. It depends on the up- and downregulation exerted by specific molecules. We report here that HCCR-1, previously shown to play an oncogenic role in human cancers, induces epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) in human and mouse, respectively. The stem… CONTINUE READING

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