Transdiagnostic Symptom Clusters and Associations With Brain, Behavior, and Daily Function in Mood, Anxiety, and Trauma Disorders.

@article{Grisanzio2018TransdiagnosticSC,
  title={Transdiagnostic Symptom Clusters and Associations With Brain, Behavior, and Daily Function in Mood, Anxiety, and Trauma Disorders.},
  author={Katherine A. Grisanzio and Andrea N. Goldstein-Piekarski and Michelle Yuyun Wang and Abdullah P Rashed Ahmed and Zoe Samara and Leanne M. Williams},
  journal={JAMA psychiatry},
  year={2018},
  volume={75 2},
  pages={201-209}
}
Importance The symptoms that define mood, anxiety, and trauma disorders are highly overlapping across disorders and heterogeneous within disorders. It is unknown whether coherent subtypes exist that span multiple diagnoses and are expressed functionally (in underlying cognition and brain function) and clinically (in daily function). The identification of cohesive subtypes would help disentangle the symptom overlap in our current diagnoses and serve as a tool for tailoring treatment choices… CONTINUE READING