Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.

  title={Transdiagnostic Associations Between Functional Brain Network Integrity and Cognition.},
  author={Julia M. Sheffield and Sridhar Kandala and Carol A. Tamminga and Godfrey D. Pearlson and Matcheri S. Keshavan and John A. Sweeney and Brett A. Clementz and Dov B. Lerman-Sinkoff and S Kristian Hill and Deanna M. Barch},
  journal={JAMA psychiatry},
  volume={74 6},
Importance Cognitive impairment occurs across the psychosis spectrum and is associated with functional outcome. However, it is unknown whether these shared manifestations of cognitive dysfunction across diagnostic categories also reflect shared neurobiological mechanisms or whether the source of impairment differs. Objective To examine whether the general cognitive deficit observed across psychotic disorders is similarly associated with functional integrity of 2 brain networks widely… CONTINUE READING
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