Transdermal permeation of neutral molecules by skin electroporation.

  title={Transdermal permeation of neutral molecules by skin electroporation.},
  author={Rita Vanbever and Maryse Leroy and V{\'e}ronique Pr{\'e}at},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={54 3},
Electroporation of skin has recently been shown to enhance transport of charged molecules across skin by up to four orders of magnitude. This study demonstrates that high-voltage pulses can also increase transdermal permeation of two neutral model solutes, i.e. mannitol and water, up to 100-fold. The elevated flux results from the persistent increase in skin permeability following electroporation, rather than from electro-osmosis during pulsing. Control on transport was achieved by controlling… CONTINUE READING

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