Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application.

@article{Luke1987TransdermalNI,
  title={Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application.},
  author={Robert Luke and Norman Sharpe and R. C. Coxon},
  journal={Journal of the American College of Cardiology},
  year={1987},
  volume={10 3},
  pages={642-6}
}
Continuous application of transdermal nitroglycerin appears to result in tolerance to the antianginal effect. In a double-blind study the effects of continuous (24 h/day) and intermittent (16 h/day) application of transdermal nitroglycerin in a dosage of 10 mg/day were compared with the effects of placebo in 12 patients with chronic stable angina receiving treatment with beta-adrenergic blocking or calcium channel blocking agents. Exercise performance was assessed 2 to 4 hours after initial… CONTINUE READING