Transdermal delivery of tea catechins and theophylline enhanced by terpenes: a mechanistic study.

@article{Fang2007TransdermalDO,
  title={Transdermal delivery of tea catechins and theophylline enhanced by terpenes: a mechanistic study.},
  author={Jia-You Fang and Tung-Hu Tsai and Yu-Ying Lin and Wen-Wen Wong and Meng-Nan Wang and Jeng-Fen Huang},
  journal={Biological & pharmaceutical bulletin},
  year={2007},
  volume={30 2},
  pages={343-9}
}
Using in vitro and in vivo techniques, terpenes were evaluated as enhancers to improve the skin permeation of therapeutically active agents derived from tea, including tea catechins and theophylline. The in vitro permeation was determined by Franz cells. The skin deposition and subcutaneous amounts of drugs sampled by microdialysis were evaluated in vivo. Terpenes varied in their activities of enhancing drug permeation. The oxygen-containing terpenes were effective enhancers of drug permeation… CONTINUE READING

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