Transdermal delivery of mixnoxidil with block copolymer nanoparticles.

  title={Transdermal delivery of mixnoxidil with block copolymer nanoparticles.},
  author={Jongwon Shim and Hyung Seok Kang and Won-Seok Park and Sang-Hun Han and Junoh Kim and Ih-seop Chang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={97 3},
We evaluated the effect of hydrodynamic size of self-assembled nanoparticles on skin penetration of minoxidil in vitro and in vivo. Self-assembled 40- and 130-nm nanoparticles, both containing minoxidil, were prepared by solvent evaporation of poly(-caprolactone)-block-poly(ethyleneglycol) and were applied onto the skin of both hairy and hairless guinea pigs in the Franz diffusion cell. In hairy guinea pig skin, the permeation of the minoxidil that incorporated in 40-nm nanoparticles was 1.5… CONTINUE READING